Are Macbeth’s paranoia due to his own weakness?

I beilieve that Macbeth's paranioa is due to both is own weakness as well as consequences. At first it began with just him as a weaker spined man. Lady Macbeth shows this. The thing though is that once he began to kill more and more men his conscience came into play and this leaded into more and more paranoia being present. All in all though the paranioa felt leads into not only his weakness but also consequences from the men he killed.